Transcriptomic Approaches to Understanding Multiple Chemosensory Systems
Speaker
Dr. Larson holds a B.S. degree in Physiology and Neurobiology from the University of Connecticut and a PhD in Physiology from University of Colorado. His graduate work was under the mentorship of Dr. Catherine Proenza and focused on the mechanism behind decline of sinoatrial pacemaker activity with advancing age. After graduate school, he began postdoctoral work under the mentorship of Drs. Sue Kinnamon and Tom Finger at the University of Colorado. In those years, he focused on cell signaling from taste buds to the central nervous system. His postdoctoral time also included mentoring by Dr. Vijay Ramakrishnan where he did translational research examining the role of specialized nasal chemosensory cells in the development of inflammatory diseases including chronic rhinosinusitis. Since 2017, he has held a faculty appointment with the Department of Otolaryngology. In this time he focused on learning many types of bioinformatic analyses and began applying them to his field of research. Since then, he has been the sole bioinformatician on multiple R01 projects, mostly in the field of chemosensory sciences. Additionally, he is the PI of an Early Career R21 from NIDCD. The goals of this project are to study nasal solitary chemosensory cells in a mouse model using advanced techniques such as tissue clearing, light sheet imaging, and single cell RNA-sequencing. Presently, Dr. Larson balances time focusing on his own research interests and consulting with other PIs in closely related fields to perform bioinformatic analyses.
Disclosure: Dr. Larson has no relevant financial relationships to disclose.
Course Description
In this lecture, the speaker will present many of the projects with which he is currently affiliated and share his primary research interests and give an overview of the types of bioinformatic analyses in his skillset that can be applied to many areas of research.
Educational Objectives
- Taste transduction pathways are used in multiple chemosensory systems, not just gustation.
- Nasal solitary chemosensory cells utilize taste transduction pathways, and serve a protective role in the airway
- There are many applications to RNA-sequencing technologies. Selecting the proper techonolgoy and analysis strategty is critical to designing an experiment.
Contact
PDMContinuingEd@dental.upenn.edu