Bioinstructive Materials Regulate Cell Behavior in Inflammation and Regeneration
Speaker
Kyle Vining, DDS, PhD is a dentist-scientist at Dana-Farber Cancer Institute and the Wyss Institute for Biologically Inspired Engineering at Harvard University. He investigates the impact of biophysical cues on cell behavior in fibrotic disease and regeneration. He earned his Ph.D. in Bioengineering with David Mooney at Harvard School of Engineering and Applied Sciences, D.D.S. from the University of Minnesota School of Dentistry, and B.S. in biomedical engineering from Northwestern University. He is currently funded by a NIH Pathway to Independence Award (K99) from the NIDCR. His Ph.D. was supported by a NIH Mentored Clinical Scientist Research Career Development Award (K08). He also completed a fellowship in the Medical Research Scholars Program at the NIH. He is the recipient of several awards, including an Emerging Technology Award from the Royal Society of Chemistry, first place in the AADOCR Junior and Senior Hatton Competitions, and first place in the IADR Junior Hatton Competition. He practices restorative dentistry at Brookline Dental Specialists.
Disclosure: Dr. Vining has no relevant financial relationships to disclose.
Course Description
Fibrosis and remodeling of extracellular matrix are involved in many diseases affecting oral health, such as tumors, wound healing, and chronic inflammation. During fibrosis, tissues undergo changes in their viscoelastic properties, i.e., how they resist deformation like a solid and dissipate stress over time like a fluid. My research program determines the impact of viscoelasticity on inflammation in fibrotic tissues and develops new immune therapies in cancer and regeneration.
Educational Objectives
- learn how fibrotic extracellular matrix regulates inflammation
- learn approaches to investigate mechanobiology of inflammation
- learn about the role of myeloid cells in hematopoietic malignancy and head and neck cancer
- learn about new materials for regenerative dentistry
Contact
For information, please contact Penn Dental Medicine Continuing Dental Education at:
PDMContinuingEd@dental.upenn.edu